- EBT-101, first-in-human CRISPR-based one-time gene therapy to be evaluated in individuals with HIV
- Initiation of EBT-101 Phase 1/2 clinical trial expected later this year
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SAN FRANCISCO, Sept. 15, 2021 (GLOBE NEWSWIRE) -- Excision BioTherapeutics, Inc., the developer of CRISPR-based therapies intended to cure viral infectious diseases, today announced that the U.S. Food and Drug Administration (FDA) has accepted the Investigational New Drug (IND) application for EBT-101, a CRISPR-based therapeutic candidate in development as a potential functional cure for chronic HIV. The IND clearance enables Excision to initiate a first-in-human Phase 1/2 clinical trial to evaluate the safety, tolerability, and efficacy of EBT-101 in individuals living with human immunodeficiency virus type 1 (HIV).
'The clearance of our IND application for EBT-101 represents an important milestone for Excision and is the result of years of commitment to developing a functional cure for individuals living with HIV,' said Daniel Dornbusch, Chief Executive Officer of Excision. 'Although antiviral treatments can manage HIV infection, they require life-long treatment, cause side effects, and do not provide the possibility of a functional cure. We are grateful for the FDA's engaged review and acceptance of the IND for EBT-101 and look forward to initiating the Phase 1/2 clinical trial later this year.'
EBT-101, an in vivo CRISPR-based therapeutic designed to excise HIV proviral DNA, is a unique gene therapy that leverages CRISPR's evolutionary history as a viral defense system in bacteria. In preclinical studies, it has demonstrated the ability to excise HIV proviral DNA in multiple cell lines: human primary cells as well as multiple animal models including non-human primates. EBT-101 utilizes an adeno-associated virus (AAV) to deliver a one-time treatment intended to functionally cure HIV infections. The investigational program employs CRISPR-Cas9 and two guide RNAs which target three sites within the HIV genome, thereby excising large portions of the HIV genome and minimizing potential viral escape.
Lisa Danzig, MD, Excision's Chief Medical Officer, added, 'EBT-101 has demonstrated removal of proviral DNA in multiple animal models and offers an opportunity for individuals living with HIV to potentially cease life-long therapies. The Excision team looks forward to this important collaboration with our principal investigators, scientific advisors and regulators, to conduct a safe and informative trial with this first-in-class approach to a viral disease target previously considered to be incurable.'
About Excision BioTherapeutics, Inc.
Excision BioTherapeutics, Inc. is a biotechnology company developing CRISPR-based therapies intended to cure viral infectious diseases. Excision is focused on improving the lives of chronically ill patients by excising viral genomes from infected individuals. By using CRISPR in unique ways, the Company has demonstrated the first functional cure for HIV in animals. Excision is developing technologies and intellectual property developed at the Khalili lab at Temple University and the Doudna lab at U.C. Berkeley. Excision is located in San Francisco, California and is supported by ARTIS Ventures, GreatPoint Ventures, Norwest Venture Partners, Adjuvant Capital, Cota Capital, Celesta Capital, IndusAge Partners, Loreda Holdings, Olive Tree, Anzu Partners, SilverRidge Venture Partners, Oakhouse Ventures, and Gaingels. For more information, please visit www.excision.bio.
Calendarique 1 2021
Contacts:
Investors
Eric Ando
Burns McClellan, Inc.
212-213-0006
eando@burnsmc.com
Media
Robert Flamm, Ph.D. / Harrison Wong
Burns McClellan, Inc.
212-213-0006
rflamm@burnsmc.com / hwong@burnsmc.com
Wireshark is an open source, sophisticated and highly acclaimed network analyzer software used by network professionals around the world for network traffic troubleshooting, analysis, software and protocol development. Supports a wide range of capture file formats. With Wireshark, you can capture data 'off the wire' from a live network connection, as well as to read from and write to popular. Freemake 3.2.1.5 Change Log Add info. Freemake 3.2.1.5 Screenshots. Upload screenshot. OldVersion.com provides free. software downloads for old versions of programs, drivers and games. Upload Software; Blog; Design by Jenox. OldVersion.com Points System. When you upload software to oldversion.com you get rewarded by points.
Description
Calendarique 1 2020
Name: Alfred for Mac
Version: 3.2.1
Release Date: 08 Dec 2016
Mac Platform: Intel
OS version:OS X 10.9 or later
Processor type(s) & speed: 64-bit
Includes: K
Activation: Use the included Patcher (Courtesy CORE) – Click on 'Patch' select 'Alfred 3.app' and click on 'Save'
Web Site: https://www.alfredapp.com/
One chat pro 2 4 download free. Overview:
Alfred is an award-winning productivity application for OS X. Alfred saves you time when you search for files online or on your Mac. Be more productive with hotkeys, keywords, and file actions at your fingertips.
Loads of app-launching, file-searching goodness – free for you to download and use with no strings attached. Alfred is the ultimate productivity tool for your Mac. Get it and see for yourself.
What's New in Version 3.2.1:
General Improvements
・Update markdown helper to correctly interpret list items (4 space instead of 2 space)
・Note that if you are using Alfred 3.2 or earlier, the update change log will render incorrectly until you update to 3.2.1
・Improved loading of 1Password 6.5+ 3rd party integration data
・Update Google Drive default web search URL to latest, fixing space encoding issue
・Make the usage stats header text selectable in Alfred's preferences
Workflows
・Add new 'Play Sound' output object
・Play sounds from the System sound bank
・Play custom aif / m4a files from within the workflow's folder
・Replace out {query} before snippet dynamic placeholders in 'Copy to Clipboard' workflow object allowing for:
・{cursor} positioning to work correctly when also using {query}
・Passed in {query} to contain dynamic snippet placeholders such as {cursor}
・Add content type tree support to the File Action trigger making it easier to show actions for type groups
・For example, add +public.image as a file type for an action to show for all files which conform to this type
・Add workflow info to the script task error dialog to help identify and debug issues
・Improved rendering in the Workflows list in Alfred's preferences
・Added option to show ‘Last Modified' date in Workflows list
Clipboard and Snippets
・Correctly calculate the visible length rather than underlying length of a snippet when positioning {cursor}
・More efficient rejection of keyword matching when checking for auto expanding snippets
・Work around macOS bug regarding mis-reported fn mod key being registered during text expansion
・More effective tidy up of expired clipboard history data
File System
・Add new 'Copy File to Clipboard' file action which copies file rather than path
・Useful for copying file for subsequent pasting into e.g. Mail.app
・Consolidated single and multiple file action code for better efficiency
FilesIthoughtsx 3.2 download free download.
Tree 2 0 3 – store ideas and organize info. Alfred 3.2.1
│── Alfred_3.2.1_768.dmg (2.82 MB)
└─ cr-alfred3.zip (479.8 kB)
Contacts:
Investors
Eric Ando
Burns McClellan, Inc.
212-213-0006
eando@burnsmc.com
Media
Robert Flamm, Ph.D. / Harrison Wong
Burns McClellan, Inc.
212-213-0006
rflamm@burnsmc.com / hwong@burnsmc.com
Wireshark is an open source, sophisticated and highly acclaimed network analyzer software used by network professionals around the world for network traffic troubleshooting, analysis, software and protocol development. Supports a wide range of capture file formats. With Wireshark, you can capture data 'off the wire' from a live network connection, as well as to read from and write to popular. Freemake 3.2.1.5 Change Log Add info. Freemake 3.2.1.5 Screenshots. Upload screenshot. OldVersion.com provides free. software downloads for old versions of programs, drivers and games. Upload Software; Blog; Design by Jenox. OldVersion.com Points System. When you upload software to oldversion.com you get rewarded by points.
Description
Calendarique 1 2020
Name: Alfred for Mac
Version: 3.2.1
Release Date: 08 Dec 2016
Mac Platform: Intel
OS version:OS X 10.9 or later
Processor type(s) & speed: 64-bit
Includes: K
Activation: Use the included Patcher (Courtesy CORE) – Click on 'Patch' select 'Alfred 3.app' and click on 'Save'
Web Site: https://www.alfredapp.com/
One chat pro 2 4 download free. Overview:
Alfred is an award-winning productivity application for OS X. Alfred saves you time when you search for files online or on your Mac. Be more productive with hotkeys, keywords, and file actions at your fingertips.
Loads of app-launching, file-searching goodness – free for you to download and use with no strings attached. Alfred is the ultimate productivity tool for your Mac. Get it and see for yourself.
What's New in Version 3.2.1:
General Improvements
・Update markdown helper to correctly interpret list items (4 space instead of 2 space)
・Note that if you are using Alfred 3.2 or earlier, the update change log will render incorrectly until you update to 3.2.1
・Improved loading of 1Password 6.5+ 3rd party integration data
・Update Google Drive default web search URL to latest, fixing space encoding issue
・Make the usage stats header text selectable in Alfred's preferences
Workflows
・Add new 'Play Sound' output object
・Play sounds from the System sound bank
・Play custom aif / m4a files from within the workflow's folder
・Replace out {query} before snippet dynamic placeholders in 'Copy to Clipboard' workflow object allowing for:
・{cursor} positioning to work correctly when also using {query}
・Passed in {query} to contain dynamic snippet placeholders such as {cursor}
・Add content type tree support to the File Action trigger making it easier to show actions for type groups
・For example, add +public.image as a file type for an action to show for all files which conform to this type
・Add workflow info to the script task error dialog to help identify and debug issues
・Improved rendering in the Workflows list in Alfred's preferences
・Added option to show ‘Last Modified' date in Workflows list
Clipboard and Snippets
・Correctly calculate the visible length rather than underlying length of a snippet when positioning {cursor}
・More efficient rejection of keyword matching when checking for auto expanding snippets
・Work around macOS bug regarding mis-reported fn mod key being registered during text expansion
・More effective tidy up of expired clipboard history data
File System
・Add new 'Copy File to Clipboard' file action which copies file rather than path
・Useful for copying file for subsequent pasting into e.g. Mail.app
・Consolidated single and multiple file action code for better efficiency
FilesIthoughtsx 3.2 download free download.
Tree 2 0 3 – store ideas and organize info. Alfred 3.2.1
│── Alfred_3.2.1_768.dmg (2.82 MB)
└─ cr-alfred3.zip (479.8 kB)
Reactor changes
The Maven reactor is now pluggable (MNG-5578). This feature required the introduction of a new custom Guice scope called @SessionScoped as we need to inject the MavenSession into the reactor right after the creation the MavenSession and before the execution of the build. The reactor behaves as a special type of artifact repository that provides the current behaviour users expect when building multi-module projects. New implementations can provide different semantics which can potentially provide new ways for multi-module projects to build, or to fix/add new features like resolving test JARs properly from the reactor. Now that the implementation is pluggable we can always default to the existing behaviour and allow people to try new behavior with a feature toggle.
The reactor now limits the projects that are exposed internally when --projects is used (MNG-5557). What happened previously is that all the projects in the reactor would still be available for resolution even if you restricted the number of projects being built using --projects. This behaviour is now explicit: what you specify using --projects is what you will build and resolve against, if a project you need is not present in the constrained set the local repository will be consulted. There are cases where you may still want access to the projects that are normally part of the build but not currently being built, and those projects are tracked (MNG-5582) and available in the MavenSession. It is also now possible to exclude projects from the reactor when using the -am and -amd options (MNG-5230). If you select a project to build and its dependents (-amd) you can exclude one or more of the dependents with a command like the following: mvn -amd --projects foo,bar,!dependent-of-bar.
These combined changes above will allow us to make new implementation of the Maven reactor with improved/different behaviour. For example, this could potentially allow you to step into a directory and run Maven and have Maven pick up the projects surrounding the project you're building instead of going to local repository. We can experiment with different implementations and let users toggle between them until we ultimately decide on the right behaviour. Lots of user complain about the behaviour of the reactor and this allows stepwise improvement.
